July , 2019

Tofacitinib is currently being studied for use in Vitiligo. One of the central pathways of vitiligo that seems to be important to the disease progression is the interferon-gamma signaling pathway. Involved in this pathway are the JAK receptors. Because of this, the use of a JAK receptor can be used to block the pathway and therefore block the progression of the disease and help induce repigmentation.

Oxytocin is a naturally occurring peptide hormone in the human body that is produced by the hypothalamus. This hormone plays a role in human social bonding, sexual reproduction, and childbirth. Currently, a synthetic form of oxytocin is used as a medication to help induce labor in patients who are medically indicated and to help control postpartum bleeding. It is available as a solution for intramuscular (IM) and intravenous (IV ) injection.

Cholestyramine is a bile acid sequestering agent that was approved by the FDA for use in hyperlipidemia (high cholesterol). By forming a complex with bile acids that cannot be absorbed by the body, cholestyramine prevents recycling of bile acid through the process of enterohepatic recirculation. Due to this, the bile acids lost in the fecal matter need to be replaced. Since bile acids are created from cholesterol, this causes the overall cholesterol level to decrease.