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Metformin HCL/Progesterone/Azelaic Acid Cream Compounded
Metformin is an anti-diabetic medication and is generally the preferred initial pharmacologic agent for the treatment of diabetes mellitus 2. It is also used for antipsychotic-induced weight gain, polycystic ovary syndrome (PCOS), gestational diabetes mellitus, and other conditions. Here at CareFirst Specialty Pharmacy, we have the facility capable of compounding metformin into different dosage forms such as creams and capsules to best fit your needs. You may buy Metformin from CareFirst Specialty Pharmacy with a valid prescription from your prescriber.
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Price: as low as $79.95
Please Note: Due to market volatility, prices are subject to change. Please contact us for the most current pricing.
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Select the action that best fits how you'd like us to handle the prescription.
This medication requires a prescription.
To process your order we will require a prescription from you or your Prescriber. We will only compound and dispense upon receipt of a valid patient specific prescription.
- Your prescriber can mail or fax in the prescription
- You can mail in the original prescription
- We can contact your prescriber for you
- You can transfer your prescription from another pharmacy
Are you a licensed Prescriber?
Choose the option that best fits how you’d like to send scripts or connect with us.
Fax Your Prescription
Fax (800) 786-1405 or (844) 922-7379 and we’ll process it right away.
Phone In
Call our pharmacists at (844) 822-7379 with prescription details.
Request More Info
Complete the prescriber form and we’ll follow up quickly.
Email Our Team
[email protected] for questions, refills, or status updates.
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Pharmacy Info
We are a nationally accredited PCAB compounding pharmacy and a .Pharmacy verified website. A verified .Pharmacy website designation ensures our patients and prescribing partners that our website is verified and safe.
https://safe.pharmacy/buy-safely/?url=cfspharmacy.pharmacy
Drug Description
Actual product image may vary.
Product Info
Clinical content written by Julia Ossman, 2027 PharmD Candidate, Philadelphia College of Pharmacy
Metformin HCl / Progesterone / Azelaic Acid Cream
This compounded topical cream combines metformin HCl, progesterone, and azelaic acid to help manage the dermatologic effects of polycystic ovary syndrome (PCOS) and acne vulgaris. Together, these medications work to reduce breakouts and other skin changes linked to these conditions.
Pronunciation: MET-for-min HCl / proe-JESS-te-rone / aye-ZAY-lay-ik ASS-id
Active Ingredients & How They Work
Metformin — Drug class: biguanide. Typically used orally as a first-line agent for type 2 diabetes, metformin enhances insulin sensitivity by reducing gluconeogenesis and activating AMP-activated protein kinase (AMPK), which inhibits gluconeogenic gene transcription.
Progesterone — Drug class: progestogen. Commonly used to prevent endometrial hyperplasia in patients taking conjugated estrogen and for secondary amenorrhea. It acts on two main receptor types — nuclear (PR-A and PR-B) and non-nuclear — each driving different transcriptional activity.
Azelaic Acid — Drug class: dicarboxylic acid. Used for acne and rosacea, it works through antibacterial, keratolytic, depigmenting, antioxidant, and anti-inflammatory mechanisms that kill bacteria and reduce redness and swelling.
Possible Side Effects
Common side effects may include burning, redness, itching, and dryness at the application site.
⚠️ Low blood sugar: Tell your doctor if you notice dizziness, headache, shakiness, irregular heartbeat, or hunger.
🚨 Allergic reaction: Seek immediate medical help if you experience swelling of the face, trouble breathing, rash, hives, or itching.
Drug Interactions
Do not use this medication with alcohol. Let your prescriber know about all medications you are taking, as they may interact with this cream.
Warning: Do not use this medication if you have active or a history of breast cancer, blood clots (e.g., pulmonary embolism), or arterial thromboembolic disease (e.g., stroke).
Administration & Dosing
Apply this medication topically exactly as prescribed. Contact your healthcare provider for specific dosing instructions.
Pregnancy, Breastfeeding & Pediatrics
This medication may be recommended against use in pregnant or breastfeeding patients, and careful monitoring may be required. It may or may not be recommended for pediatric patients depending on indication and patient history. Consult your provider to learn more.
⚠️ Disclaimer: This information is generalized and not intended as specific medical advice. If you have questions about the use of your prescription, please contact your prescriber.
References
- Afshar, K., Adibfard, S., Nikbakht, M.H., Rastegarnasab, F., Pourmahdi-Boroujeni, M. and Abtahi-Naeini, B. (2024). A Systematic Review on Clinical Evidence for Topical Metformin: Old Medication With New Application. Health Science Reports, 7: e70281. https://doi.org/10.1002/hsr2.70281
- U.S. Food and Drug Administration. PROMETRIUM (progesterone, USP) capsules 100 mg; capsules 200 mg [package insert]. Silver Spring (MD): U.S. Food and Drug Administration; 2026 Feb. Package insert
- National Library of Medicine (US). Azelaic acid topical [Internet]. Bethesda (MD): National Library of Medicine (US); revised 2016 Dec 15. medlineplus.gov
- Feng X, Shang J, Gu Z, Gong J, Chen Y, Liu Y. Azelaic Acid: Mechanisms of Action and Clinical Applications. Clin Cosmet Investig Dermatol. 2024 Oct 22;17:2359-2371. doi: 10.2147/CCID.S485237. PMID: 39464747; PMCID: PMC11512533.
- U.S. Food and Drug Administration. Finacea (azelaic acid) gel, 15% [package insert]. Silver Spring (MD): U.S. Food and Drug Administration; 2010. Package insert
- U.S. Food and Drug Administration. GLUCOPHAGE (metformin hydrochloride) tablets; GLUCOPHAGE XR (metformin hydrochloride) extended-release tablets [package insert]. Silver Spring (MD): U.S. Food and Drug Administration; 2018. Package insert
- Kolatorova L, Vitku J, Suchopar J, Hill M, Parizek A. Progesterone: A Steroid with Wide Range of Effects in Physiology as Well as Human Medicine. Int J Mol Sci. 2022 Jul 20;23(14):7989. doi: 10.3390/ijms23147989. PMID: 35887338; PMCID: PMC9322133.
Active Ingredients
Metformin, Progesterone, Azalaic Acid
Directions
Consult your prescriber.
Instructions
Use the medication as prescribed by your doctor. The information provided is not intended to cover all possible uses. This information is generalized and not intended as specific medical advice. If you have questions about the use of your prescription, please contact your prescriber.
Shipping
Troches and suppositories require refrigeration (ice packs) and will incur an extra charge of $19.95 per order.
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We are a nationally accredited PCAB compounding pharmacy and a .Pharmacy verified website. A verified .Pharmacy website designation ensures our patients and prescribing partners that our website is verified and safe.
https://safe.pharmacy/buy-safely/?url=cfspharmacy.pharmacy
Actual product image may vary.
Clinical content written by Julia Ossman, 2027 PharmD Candidate, Philadelphia College of Pharmacy
Metformin HCl / Progesterone / Azelaic Acid Cream
This compounded topical cream combines metformin HCl, progesterone, and azelaic acid to help manage the dermatologic effects of polycystic ovary syndrome (PCOS) and acne vulgaris. Together, these medications work to reduce breakouts and other skin changes linked to these conditions.
Pronunciation: MET-for-min HCl / proe-JESS-te-rone / aye-ZAY-lay-ik ASS-id
Active Ingredients & How They Work
Metformin — Drug class: biguanide. Typically used orally as a first-line agent for type 2 diabetes, metformin enhances insulin sensitivity by reducing gluconeogenesis and activating AMP-activated protein kinase (AMPK), which inhibits gluconeogenic gene transcription.
Progesterone — Drug class: progestogen. Commonly used to prevent endometrial hyperplasia in patients taking conjugated estrogen and for secondary amenorrhea. It acts on two main receptor types — nuclear (PR-A and PR-B) and non-nuclear — each driving different transcriptional activity.
Azelaic Acid — Drug class: dicarboxylic acid. Used for acne and rosacea, it works through antibacterial, keratolytic, depigmenting, antioxidant, and anti-inflammatory mechanisms that kill bacteria and reduce redness and swelling.
Possible Side Effects
Common side effects may include burning, redness, itching, and dryness at the application site.
⚠️ Low blood sugar: Tell your doctor if you notice dizziness, headache, shakiness, irregular heartbeat, or hunger.
🚨 Allergic reaction: Seek immediate medical help if you experience swelling of the face, trouble breathing, rash, hives, or itching.
Drug Interactions
Do not use this medication with alcohol. Let your prescriber know about all medications you are taking, as they may interact with this cream.
Warning: Do not use this medication if you have active or a history of breast cancer, blood clots (e.g., pulmonary embolism), or arterial thromboembolic disease (e.g., stroke).
Administration & Dosing
Apply this medication topically exactly as prescribed. Contact your healthcare provider for specific dosing instructions.
Pregnancy, Breastfeeding & Pediatrics
This medication may be recommended against use in pregnant or breastfeeding patients, and careful monitoring may be required. It may or may not be recommended for pediatric patients depending on indication and patient history. Consult your provider to learn more.
⚠️ Disclaimer: This information is generalized and not intended as specific medical advice. If you have questions about the use of your prescription, please contact your prescriber.
References
- Afshar, K., Adibfard, S., Nikbakht, M.H., Rastegarnasab, F., Pourmahdi-Boroujeni, M. and Abtahi-Naeini, B. (2024). A Systematic Review on Clinical Evidence for Topical Metformin: Old Medication With New Application. Health Science Reports, 7: e70281. https://doi.org/10.1002/hsr2.70281
- U.S. Food and Drug Administration. PROMETRIUM (progesterone, USP) capsules 100 mg; capsules 200 mg [package insert]. Silver Spring (MD): U.S. Food and Drug Administration; 2026 Feb. Package insert
- National Library of Medicine (US). Azelaic acid topical [Internet]. Bethesda (MD): National Library of Medicine (US); revised 2016 Dec 15. medlineplus.gov
- Feng X, Shang J, Gu Z, Gong J, Chen Y, Liu Y. Azelaic Acid: Mechanisms of Action and Clinical Applications. Clin Cosmet Investig Dermatol. 2024 Oct 22;17:2359-2371. doi: 10.2147/CCID.S485237. PMID: 39464747; PMCID: PMC11512533.
- U.S. Food and Drug Administration. Finacea (azelaic acid) gel, 15% [package insert]. Silver Spring (MD): U.S. Food and Drug Administration; 2010. Package insert
- U.S. Food and Drug Administration. GLUCOPHAGE (metformin hydrochloride) tablets; GLUCOPHAGE XR (metformin hydrochloride) extended-release tablets [package insert]. Silver Spring (MD): U.S. Food and Drug Administration; 2018. Package insert
- Kolatorova L, Vitku J, Suchopar J, Hill M, Parizek A. Progesterone: A Steroid with Wide Range of Effects in Physiology as Well as Human Medicine. Int J Mol Sci. 2022 Jul 20;23(14):7989. doi: 10.3390/ijms23147989. PMID: 35887338; PMCID: PMC9322133.
Metformin, Progesterone, Azalaic Acid
Consult your prescriber.
Use the medication as prescribed by your doctor. The information provided is not intended to cover all possible uses. This information is generalized and not intended as specific medical advice. If you have questions about the use of your prescription, please contact your prescriber.
Troches and suppositories require refrigeration (ice packs) and will incur an extra charge of $19.95 per order.
Customer Reviews
No reviews yet