Estriol/Estradiol Compounded

As low as $42.95

Our expert compounding pharmacists compound Estriol/Estradiol (Bi-Est) 80/20, 70/30, 50/50 into topical creams, troches and capsules. Can be combined with progesterone or testosterone.

Estriol/Estradiol Compounded
Estriol/Estradiol Compounded

This medication requires a prescription.

To process your order we will require a prescription from you or your Prescriber. We will only compound and dispense upon receipt of a valid patient specific prescription. Please note that our compounds are exclusively provided for individual patient and are not for office use.

  • Your prescriber can mail or fax in the prescription
  • You can mail in the original prescription
  • We can contact your prescriber for you
  • You can transfer your prescription from another pharmacy

Please click here to start the process.


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We are a nationally accredited PCAB compounding pharmacy and a .Pharmacy verified website. A verified .Pharmacy website designation ensures our patients and prescribing partners that our website is verified and safe.

This is a compounded medication specifically made for you based on a prescription from your licensed physician.

Estradiol – Compounded Topical Cream: Estradiol is a synthetic form of estrogen, the female sex hormone. Estrogen has many functions in both males and females. In females, estrogens are produced when a follicle develops on the ovary. Rising and falling levels of estrogen affects multiple organs, including the uterus, pituitary and adrenal glands. Estradiol is used in a variety of medications for both men and women. It may be used as a part of your treatment plan for:

    - Symptoms of menopause
    - Osteoporosis prevention
    - Ovarian failure
    - Specific cancer treatment
    - Feminizing hormone therapy

Menopause and Estradiol Cream:
 In menopausal and postmenopausal women, levels of estrogen decrease. This can cause a wide variety of symptoms, including vaginal wall changes, dryness, pain during sex, and itching. It is reported that 45% of postmenopausal women may suffer from these vaginal changes.1Estradiol cream is prescribed to help replace estrogen levels and improve symptoms.

Feminizing Hormone Therapy: Specifically compounded estradiol creams and gels may be helpful and convenient for some transgender women. However, they must work closely with a compounding pharmacist and physician for the dosing required to achieve physiologic blood levels.

Side Effects and Other Helpful Information: Side effects of estradiol cream may include:
    - Infection
    - Vaginitis, vaginal discharge
    - Cerebrovascular accident
    - Breast cancer
    - Headache
    - Endometrial disease
    - Skin rash
    - Weight gain
    - Back pain

Taking estrogen replacements, such as estradiol, may increase your risk of developing breast or uterine cancer. 
Progestins may be prescribed along with estradiol. Pregnant women should not take estradiol. 
Estradiol can pass into the breastmilk and may decrease breastmilk supply. 
If you suffer from liver disease, blood clotting disorder, hormone-dependent cancer, allergy to certain medications or unusual vaginal bleeding, do not use estradiol cream. 
Please speak to your physician immediately if you experience any side effects related to use of estradiol cream. 
Use the medication as prescribed by your doctor. 
The information provided is not intended to cover all possible uses. This information is generalized and not intended as specific medical advice. If you have questions about the use of your prescription, please contact your prescriber.

References:- 1. Lindhal, Sarah. Reviewing the options for local estrogen treatment of vaginal atrophy. Int J Womens Health. 2014; 6: 307-312. 2. Deutsch, Madeline. Overview of Feminizing Hormone Therapy. University of California, San Francisco 3. Estradiol.


Consult your physician

We dispense this medication in an easy to use applicator, Topi-CLICK. Click here for details.

Troches and suppositories require refrigeration (ice packs) and will incur an extra charge of $19.95 per order.

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