Lovastatin Topical Cream Compounded
Lovastatin is an antihyperlipidemic agent to treat high blood cholesterol and reduce the risk of cardiovascular disease. Recent studies suggest that statins may have potential as novel treatments for diverse conditions, ranging from sepsis and inflammatory diseases to chronic wounds and bone fractures.
This medication requires a prescription.
To process your order we will require a prescription from you or your Prescriber. We will only compound and dispense upon receipt of a valid patient specific prescription. Please note that our compounds are exclusively provided for individual patient and are not for office use.
- Your prescriber can mail or fax in the prescription
- You can mail in the original prescription
- We can contact your prescriber for you
- You can transfer your prescription from another pharmacy
Are you a licensed Prescriber?
- We have convenient ways to get your prescription to us:
- Fax to (800) 786-1405 or (844) 922-7379
- Send electronically (e-prescribe) by:
- Searching for CareFirst Specialty Pharmacy in Mount Laurel, NJ 08054
- Using our NCPDP# 3151266
- Phone into (844) 822-7379
- For more information about our products and services:
- Please complete the prescriber form online
- Email us at [email protected]
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Lovastatin
By: Karan Modi
PharmD Candidate 2022
CareFirst Specialty Pharmacy
Lovastatin is an antihyperlipidemic agent to treat high blood cholesterol and reduce the risk of cardiovascular disease. Recent studies suggest that statins may have potential as novel treatments for diverse conditions, ranging from sepsis and inflammatory diseases to chronic wounds and bone fractures.
Pronunciation
(LOE va sta tin)
Other Names
Altoprev
Drug Class
HMG-CoA Reductase Inhibitor, Antihyperlipidemic, Cardiovascular agent
Mechanism of Action:
Lovastatin is a cholesterol lowering agent and it is rapidly hydrolyzed to beta-hydroxyacid which is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. It prevents the conversion of HMG-CoA to mevalonate which is rate limiting step in the biosynthesis of cholesterol.
Statins exert their anti-inflammatory effect by inhibiting the release of C-reactive peptide, chemokines, cytokines and adhesion molecules, which may make them a powerful addition to the dermatologic anti-inflammatory medication arsenal. Along with reducing inflammation, statins have the potential to heal chronic wounds by decreasing farnesyl pyrophosphate, facilitating vascular relaxation, promoting neovascularization and reducing bacterial load. A better understanding of their effects at the cellular and molecular level in skin is necessary for their future use.
Drug Interactions:
Do not take it with the following medications: Amprenavir, Atazanavir, Boceprevir, Clarithromycin, Cobicistat, Darunavir, Erythromycin, Fosamprenavir, Idelalisib, Indinavir, Itraconazole, Ketoconazole, Lopinavir, Mibefradil, Mifepristone, Nefazodone, Nelfinavir, Posaconazole, Ritonavir, Saquinavir, Telaprevir, Telithromycin, Tipranavir, Voriconazole
Consider therapy modifications with the following medications: Amiodarone, Bezafibrate, Ceritinib, Ciprofibrate, Clofibrate, Colchicine, Conivaptan, Cyclosporine, Dabigatran, Etexilate, Dalfopristin, Danazol, Daptomycin, Delavirdine, Diltiazem, Dronedarone, Duvelisib, Fenofibrate, Fenofibric Acid, Fluconazole, Fosnetupitant, Gemfibrozil, Glecaprevir, Ivosidenib, Larotrectinib, Lefamulin, Letermovir, Lomitapide, Lorlatinib, Lumacaftor, Netupitant, Niacin, Pibrentasvir, Quinupristin, Ranolazine, Verapamil
Contraindications:
- Hypersensitivity to lovastatin or any component of the formulation
- Active liver disease
- Unexplained persistent elevations of serum transaminases
- Concomitant use of strong CYP3A4 inhibitors (eg, clarithromycin, erythromycin, itraconazole, ketoconazole, nefazodone, posaconazole, voriconazole, protease inhibitors [including boceprevir and telaprevir], telithromycin, cobicistat-containing products)
- Pregnancy
- Breastfeeding
Adverse Effects:
Common side effects you might experience: abdominal pain, constipation, arthralgia, headache, flatulence, skin rash
Administration
Use this drug as ordered by your prescriber.
Dosing
Contact your healthcare provider for specific dosing instructions.
Pregnancy/Breastfeeding:
Lovastatin is contraindicated in pregnant females.
Due to the potential for serious adverse reactions in a breastfed infant, use while breastfeeding is contraindicated by the manufacturer.
Children/Pediatrics:
No data for the use of lovastatin in younger patients
Veterinary:
There is no data for the use of lovastatin in pets.
References:
- Lovastatin. Dynamed. TJU Library, Philadelphia, PA. Accessed May 26, 2021. https://www.dynamed.com/drug-monograph/lovastatin#GUID-03B19702-96EF-469D-86F8-0488B97BA1F1
- Lovastatin. Lexi-drugs. Lexicomp. TJU Library, Philadelphia, PA. Accessed May 26, 2021. http://online.lexi.com.proxy1.lib.tju.edu/lco/action/doc/retrieve/docid/patch_f/7202?cesid=9OaE1c2g7cz&searchUrl=%2Flco%2Faction%2Fsearch%3Fq%3Dlovastatin%26t%3Dname%26va%3Dlovastatin
- Stojadinovic O, Lebrun E, Pastar I, et al. Statins as potential therapeutic agents for healing disorders. Expert Rev Dermatol. 2010;5(6):689-698. https://cardiacos.net/wp-content/uploads/ArticulosMedicos/2010/2010-Statins-as-Potential-Therapeutic-Agents-for-Healing-Disorders-printer-friendly.pdf. Accessed May26, 2021.
Lovastatin
Consult your prescriber.
This is a compounded medication specifically made for you based on a prescription from your licensed physician.
Troches and suppositories require refrigeration (ice packs) and will incur an extra charge of $19.95 per order.